Based on a Century of Scientific Research

Ketosis is a well-understood physiologic process with proven therapeutic benefits, which has existed in medical literature for over 100 years.

The Mayo Clinic ran the first clinical trial on the keto diet in 1921; studying the effects it had on epileptic children. The results of their research suggest promising results for reducing seizures and easing other symptoms of the disease when entering a state of ketosis.

Below is a small collection of some of the most important and informative research papers to help support your understanding of the proven science behind Keto5.

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Ketosis, ketogenic diet and food intake control: a complex relationship

This review aims to provide a summary of the effects of a ketogenic diet (KD) on food control by analyzing the molecular and cellular mechanisms underlying hunger reduction. While ketosis has been shown to reduce hunger by releasing cholecystokinin (CCK) and inhibiting ghrelin, ketone bodies (KB) can increase food intake through AMP-activated protein kinase (AMPK) phosphorylation, gamma-aminobutyric acid (GABA) and the release and production of adiponectin. The review aims to unify the apparently contradictory data into a coherent picture.

β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence

This study investigated how different brain cell types respond to β-hydroxybutyrate (βOHB), a ketone body. They found that SH-SY5Y neuroblastoma cells and primary neurons, but not astrocytes, exposed to βOHB increased respiration and decreased PI3K-Akt-mTOR signaling. However, despite increased respiration, SH-SY5Y cells treated with βOHB reduced their overall metabolic activity and cell cycling rate, suggesting that βOHB-induced increase in neuron respiration could alleviate bioenergetic stress and limit cell senescence, which may benefit conditions like brain aging and neurodegenerative diseases.
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