This review aims to provide a summary of the effects of a ketogenic diet (KD) on food control by analyzing the molecular and cellular mechanisms underlying hunger reduction. While ketosis has been shown to reduce hunger by releasing cholecystokinin (CCK) and inhibiting ghrelin, ketone bodies (KB) can increase food intake through AMP-activated protein kinase (AMPK) phosphorylation, gamma-aminobutyric acid (GABA) and the release and production of adiponectin. The review aims to unify the apparently contradictory data into a coherent picture.