Based on a Century of Scientific Research

Ketosis is a well-understood physiologic process with proven therapeutic benefits, which has existed in medical literature for over 100 years.

The Mayo Clinic ran the first clinical trial on the keto diet in 1921; studying the effects it had on epileptic children. The results of their research suggest promising results for reducing seizures and easing other symptoms of the disease when entering a state of ketosis.

Below is a small collection of some of the most important and informative research papers to help support your understanding of the proven science behind Keto5.


Ketogenic diet in the treatment of cancer – Where do we stand?

The ketogenic diet is a promising adjuvant cancer therapy that can sensitize most cancers to standard treatment. Preclinical and clinical studies suggest that the ketogenic diet can enhance the antitumor effects of classic chemo- and radiotherapy and increase the quality of life of cancer patients. However, more molecular studies and uniformly controlled clinical trials are needed to fully understand the mechanisms of the ketogenic diet as a cancer therapy and its application in clinical practice.

Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease

Brain glucose uptake is impaired in Alzheimer's disease (AD), and increasing ketone availability to the brain via moderate nutritional ketosis has a modest beneficial effect on cognitive outcomes in mild-to-moderate AD and in mild cognitive impairment. This can be achieved through a high-fat ketogenic diet, supplements providing medium-chain triglycerides, or ketone esters. The development of therapeutic strategies for AD should consider how the underlying problem of deteriorating brain fuel supply can be corrected or delayed.

Comparison of Ketogenic Diets with and without Ketone Salts versus a Low-Fat Diet: Liver Fat Responses in Overweight Adults

This study compared the effect of a hypocaloric ketogenic diet (KD) with or without ketone supplementation (KS) and a low-fat diet (LFD) on liver fat reduction in overweight adults. The results showed that all diets significantly reduced liver fat, including in participants with nonalcoholic fatty liver disease (NAFLD), with no significant differences between the groups. The study suggests that both KDs and LFDs can be used to reduce liver fat in individuals with NAFLD.

Exogenous Ketones as Therapeutic Signaling Molecules in High-Stress Occupations: Implications for Mitigating Oxidative Stress and Mitochondrial Dysfunction in Future Research

High-stress occupations are associated with cardiometabolic diseases due to chronic stressors. Ketones, specifically R-βHB, modulate intracellular signaling cascades to promote a robust mitochondrial environment that favors reductions in oxidative stress and inflammation. The scope of this review is to detail the mechanisms of R-βHB as a signaling metabolite and the role that exogenous ketones might play in mitigating diseases in individuals serving in high-stress occupations.
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