The study aimed to investigate the biochemical benefits of ketosis in humans using a ketone ester-based form of nutrition without the need for caloric or carbohydrate restriction. Ketosis, the metabolic response to energy crisis, is a mechanism that alters oxidative fuel selection to sustain life, and it has the potential for metabolic benefits beyond starvation or diabetic crisis, which are poorly understood. The study aimed to fill this knowledge gap by studying the biochemical advantages of ketosis in humans.