Based on a Century of Scientific Research

Ketosis is a well-understood physiologic process with proven therapeutic benefits, which has existed in medical literature for over 100 years.

The Mayo Clinic ran the first clinical trial on the keto diet in 1921; studying the effects it had on epileptic children. The results of their research suggest promising results for reducing seizures and easing other symptoms of the disease when entering a state of ketosis.

Below is a small collection of some of the most important and informative research papers to help support your understanding of the proven science behind Keto5.


A Systematic Review of Intravenous β-Hydroxybutyrate Use in Humans – A Promising Future Therapy?

This systematic review aims to assess the safety and effectiveness of intravenous beta-hydroxybutyrate (BHB) as a treatment for acute conditions such as traumatic brain injury. Therapeutic ketosis is traditionally induced with dietary modification, but it is not practical for acute conditions due to the time delay involved. Intravenous administration of ketones would rapidly induce ketosis, but currently no such product exists. The review includes studies on small animals and humans, and searched the Web of Science, PubMed and EMBASE databases.

Effects of a low carbohydrate weight loss diet on exercise capacity and tolerance in obese subjects

Dietary restriction and increased physical activity are recommended for obesity treatment. Very low carbohydrate diets are used to promote weight loss, but their effects on physical function and exercise tolerance in overweight and obese individuals are largely unknown. The aim of this study was to compare the effects of a very low carbohydrate, high fat (LC) diet with a conventional high carbohydrate, low fat (HC) diet on aerobic capacity, fuel utilization during submaximal exercise, perceived exercise effort (RPE) and muscle strength.