Based on a Century of Scientific Research

Ketosis is a well-understood physiologic process with proven therapeutic benefits, which has existed in medical literature for over 100 years.

The Mayo Clinic ran the first clinical trial on the keto diet in 1921; studying the effects it had on epileptic children. The results of their research suggest promising results for reducing seizures and easing other symptoms of the disease when entering a state of ketosis.

Below is a small collection of some of the most important and informative research papers to help support your understanding of the proven science behind Keto5.


Weight loss, improved physical performance, cognitive function, eating behavior, and metabolic profile in a 12-week ketogenic diet in obese adults

The ketogenic diet is gaining popularity as a weight loss strategy. The study aimed to determine the relationship between the diet and changes in physical performance, cognitive function, eating behaviors, metabolic and hormonal profile in obese adults. The 12-week ketogenic diet was found to have significant effects on body weight and various aspects of the participants' physical and mental health, but these effects differed between men and women.

Oral β-hydroxybutyrate increases ketonemia, decreases visceral adipocyte volume and improves serum lipid profile in Wistar rats

In this study, researchers aimed to induce ketosis in rats through the oral intake of a β-hydroxybutyrate (βHB) mineral salt mixture alone, without any other dietary changes. The results showed that this approach was effective in increasing ketonemia in rats and may be a useful model for studying the effects of ketones on metabolism. The study highlights the potential for non-dietary interventions to induce ketosis.

Ketogenic diet benefits body composition and well-being but not performance in a pilot case study of New Zealand endurance athletes

In this pilot study, researchers examined the effects of a non-calorie controlled ketogenic diet on body composition and performance outcomes of endurance athletes, as well as the athletes' experiences with the diet. The study found that the ketogenic diet did not negatively impact athletic performance or body composition, and the athletes generally reported positive experiences with the diet. However, more research is needed to determine the long-term effects and feasibility of the diet for athletes.
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