Based on a Century of Scientific Research

Ketosis is a well-understood physiologic process with proven therapeutic benefits, which has existed in medical literature for over 100 years.

The Mayo Clinic ran the first clinical trial on the keto diet in 1921; studying the effects it had on epileptic children. The results of their research suggest promising results for reducing seizures and easing other symptoms of the disease when entering a state of ketosis.

Below is a small collection of some of the most important and informative research papers to help support your understanding of the proven science behind Keto5.

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Ketone Administration for Seizure Disorders: History and Rationale for Ketone Esters and Metabolic Alternatives

The ketogenic diet (KD) produces ketone bodies which have been believed to have anti-seizure effects. Experimental evidence shows that ketone bodies can have various anti-seizure properties including activation of inhibitory adenosine and ATP-sensitive potassium channels, enhancement of mitochondrial function, reduction in oxidative stress, and attenuation of excitatory neurotransmission. Although there are pragmatic challenges in administering ketone bodies in humans, the use of ketone esters or balanced ketone electrolyte formulations may largely mitigate prior concerns and induce sustained hyperketonemia to achieve therapeutic effects.

The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer

Metabolic therapy using ketogenic diets is a promising approach for brain cancer management that targets the common metabolic malady of most cancers, the aerobic fermentation of glucose. The KD lowers blood glucose and elevates blood ketones to target tumor energy metabolism. Although plasma levels of glucose and ketone bodies have been used separately to predict therapeutic success, daily glucose fluctuations can make it challenging to link changes in blood glucose and ketones to the efficacy of metabolic therapy.

Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current Literature

The glucose-lowering effects of exogenous ketones: is there therapeutic potential?

In this article, exogenous ketone supplements have been shown to be effective in stimulating ketosis, which can be used to provide energy to the brain during periods of low glucose availability, as well as in other tissues. Researchers have investigated the effects of acute ingestion of the ketone monoester on the postprandial glycaemic response in young, healthy individuals. They found that the ketone monoester resulted in a significant reduction in plasma glucose area under the curve by 16% over the 2-hour period, without further elevating insulin compared to glucose alone. This result may have potential implications for individuals with type 2 diabetes mellitus.
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