Based on a Century of Scientific Research

Ketosis is a well-understood physiologic process with proven therapeutic benefits, which has existed in medical literature for over 100 years.

The Mayo Clinic ran the first clinical trial on the keto diet in 1921; studying the effects it had on epileptic children. The results of their research suggest promising results for reducing seizures and easing other symptoms of the disease when entering a state of ketosis.

Below is a small collection of some of the most important and informative research papers to help support your understanding of the proven science behind Keto5.

Search

Gastrointestinal Effects of Exogenous Ketone Drinks are Infrequent, Mild, and Vary According to Ketone Compound and Dose

The study examines the gastrointestinal tolerability of exogenous ketone drinks during three studies. Participants reported mild and acute symptoms following KME and KS drinks, which were fully resolved by the end of the study. The study concludes that exogenous ketone drinks cause mild gastrointestinal symptoms that depend on the compound consumed, amount, time, and exercise.

Context is key: exogenous ketosis and athletic performance

Ketone bodies are synthesized from lipids during prolonged caloric deprivation and have pleiotropic effects on metabolism. They improve energetics and fuel sparing, and may be used to enhance human exercise endurance performance by mimicking advantageous aspects of starvation physiology. While exercising during endogenous ketosis may not be advantageous, the delivery of exogenous ketones creates a novel physiological state with high circulating ketone concentrations and replete carbohydrate stores, offering potential benefits for endurance performance.

Ketone Administration for Seizure Disorders: History and Rationale for Ketone Esters and Metabolic Alternatives

The ketogenic diet (KD) produces ketone bodies which have been believed to have anti-seizure effects. Experimental evidence shows that ketone bodies can have various anti-seizure properties including activation of inhibitory adenosine and ATP-sensitive potassium channels, enhancement of mitochondrial function, reduction in oxidative stress, and attenuation of excitatory neurotransmission. Although there are pragmatic challenges in administering ketone bodies in humans, the use of ketone esters or balanced ketone electrolyte formulations may largely mitigate prior concerns and induce sustained hyperketonemia to achieve therapeutic effects.

Prev
2 of 11
Next
Close